DeskTube is an Adobe Air based desktop application for YouTube. It features the ability to search/view/upload videos, post/view comments, view personal playlists, view personal subscriptions, record video, post updates to Twitter, Facebook, and even watch beautiful HD streams. You can record videos using the webcam and upload to YouTube directly from the application by logging into YouTube.
DeskTube also offers four-way video chat while watching YouTube clips. The four-way chat feature makes it possible to video conference with up to three friends at the same time. You can even use it to share the YouTube videos you’re watching with chat members, essentially creating a shared video watching experience.